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Patients with nonfluent speech, but relatively spared comprehension and repetition, may have a primary disorder of language, or may primarily have impaired attention, or conation.

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In addition, in patients with severe hepatic cirrhosis, the bupropion C max and AUC were substantially increased (mean difference: by approximately 70% and 3-fold, respectively) and more variable when compared to values in healthy volunteers; the mean bupropion half-life was also longer (29 hours in patients with severe hepatic cirrhosis vs.

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The first six are not time-varying: gender, onset age, PSPRS score at Visit 1, gait ratio (see above for definition) at Visit 1 and initial progressivity (over the first set of two visits that were at least 6 months apart).

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